After their car breaks down during a storm in the German countryside, two young American women stumble upon an isolated villa. Offering to call them a taxi, the villas owner Dr. Heiter, a retired surgeon, invites the girls inside with the promise of a glass of water and dry place to wait for help to arrive. Too late they realize that there is something not quite right about their formidable host and the girls are plunged into a nightmare so bizarre that survival might not be worth the effort. As the deranged Doctor explains his twisted vision, the two girls discover that they are soon to become closer to each other than even BFFs would ever want to be. Heiters plan is to connect the two girls, along with a third person, a hapless Japanese tourist, to each other via their gastric systems in a daring bid to be the first person to create a Siamese triplet and bring to life the first sequence of a Human Centipede.
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